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Results for "

Parasite Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Parasite (91) Akt (1) AMPK (1) Antibiotic (12) Antifolate (2) Apoptosis (4) Autophagy (3) Bacterial (15) Bcl-2 Family (2) BCRP (3) CaMK (2) Caspase (2) Cathepsin (2) Cytochrome P450 (3) Dengue virus (2) Dihydrofolate reductase (DHFR) (1) Dihydroorotate Dehydrogenase (5) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) EGFR (1) Elastase (1) Endogenous Metabolite (2) Flavivirus (2) Fungal (6) GLUT (1) HCV (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HIV (1) HSP (1) HSV (1) Isotope-Labeled Compounds (5) Microtubule/Tubulin (1) Mitophagy (1) mTOR (1) Na+/K+ ATPase (1) PARP (2) Phosphatase (7) Phosphodiesterase (PDE) (1) PI4K (1) PKA (2) PKC (1) Proteasome (2) PTEN (2) Pyroptosis (1) Reactive Oxygen Species (2) SARS-CoV (1) VEGFR (1)
By Research Areas:	Cancer (15) Infection (89) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (1)

By Targets:

Parasite (91)

Akt (1)

AMPK (1)

Antibiotic (12)

Antifolate (2)

Apoptosis (4)

Autophagy (3)

Bacterial (15)

Bcl-2 Family (2)

BCRP (3)

CaMK (2)

Caspase (2)

Cathepsin (2)

Cytochrome P450 (3)

Dengue virus (2)

Dihydrofolate reductase (DHFR) (1)

Dihydroorotate Dehydrogenase (5)

DNA Methyltransferase (1)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

EGFR (1)

Elastase (1)

Endogenous Metabolite (2)

Flavivirus (2)

Fungal (6)

GLUT (1)

HCV (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

HIV (1)

HSP (1)

HSV (1)

Isotope-Labeled Compounds (5)

Microtubule/Tubulin (1)

Mitophagy (1)

mTOR (1)

Na+/K+ ATPase (1)

PARP (2)

Phosphatase (7)

Phosphodiesterase (PDE) (1)

PI4K (1)

PKA (2)

PKC (1)

Proteasome (2)

PTEN (2)

Pyroptosis (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

VEGFR (1)

By Research Areas:

Cancer (15)

Infection (89)

Inflammation/Immunology (9)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Parasite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W104379

Arprinocid

Parasite Infection

Arprinocid is a purine analog with activity against murine Toxoplasma gondii .
HY-121493

TM2-115

Histone Methyltransferase Parasite Infection

TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .
HY-137445

Modoflaner

Parasite Infection

Modoflaner is an isophenylamide insecticide. Modoflaner may act through allosteric regulation of gamma-aminobutyric acid-gated chloride channels .

Arprinocid	Parasite	Infection
Arprinocid is a purine analog with activity against murine Toxoplasma gondii .

TM2-115	Histone Methyltransferase Parasite	Infection
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death .

Modoflaner	Parasite	Infection
Modoflaner is an isophenylamide insecticide. Modoflaner may act through allosteric regulation of gamma-aminobutyric acid-gated chloride channels .

HY-149722

Antiparasitic agent-20	Parasite	Infection
Antiparasitic agent-20 (Compound 1p) is a *parasite* inhibitor with broad antiparasitic activity. Antiparasitic agent-20 has inhibitory effects on T. brucei and T. cruzi with EC₅₀ values of 0.09 μM and 14.1 μM respectively .

HY-150066

Antimalarial agent 16	Parasite	Infection Inflammation/Immunology
Antimalarial agent 16 (Compound 4h) is a *parasite* inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC₅₀=2.0 nM) .

HY-150065

Antimalarial agent 15	Parasite	Infection Inflammation/Immunology
Antimalarial agent 15 (Compound 4e) is a *parasite* inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC₅₀=20 nM) .

HY-108387

Morantel citrate	Parasite	Infection
Morantel citrate is a veterinary anthelmintic agent that inhibits parasitic infections in cattle, sheep and goats. Morantel citrate paralyzes the nervous system of the parasite, helping the animal expel the dead parasite from the body .

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-U00295

Melarsonyl

Melarsonic acid
Parasite Infection

Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.
HY-W588212

trans-Permethrin

trans-NRDC-143
Parasite Neurological Disease

trans-Permethrin is a transconfiguration of Permethrin (HY-B0887). Permethrin is an insecticide and neurotoxin .
HY-W010986

Fmoc-N-Me-Phe-OH

Parasite Infection

Fmoc-N-Me-Phe-OH is a peptide inhibitor of Malaria Parasite .
HY-115550

Chalcone 4 hydrate

Parasite Infection

Chalcone 4 hydrate is an anti-parasite agent, inhibits the growth of Babesia and Theileria .

Melarsonyl Melarsonic acid	Parasite	Infection
Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit *parasite* potently.

trans-Permethrin trans-NRDC-143	Parasite	Neurological Disease
trans-Permethrin is a transconfiguration of Permethrin (HY-B0887). Permethrin is an insecticide and neurotoxin .

Fmoc-N-Me-Phe-OH	Parasite	Infection
Fmoc-N-Me-Phe-OH is a peptide inhibitor of Malaria Parasite .

Chalcone 4 hydrate	Parasite	Infection
Chalcone 4 hydrate is an *anti-parasite* agent, inhibits the growth of Babesia and Theileria .

HY-U00295A

Melarsonyl dipotassium Melarsonic acid dipotassium	Parasite	Infection
Melarsonyl dipotassium (Melarsonic acid dipotassium) is an anthelmintic agent which can inhibit *parasite* potently .

HY-132929

TCMDC-125431

Parasite Infection

TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
HY-132930

TCMDC-136230

Parasite Infection

TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
HY-151568

UCB7362

Parasite Infection

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits parasite growth .

TCMDC-125431	Parasite	Infection
TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

TCMDC-136230	Parasite	Infection
TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

UCB7362	Parasite	Infection
UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC₅₀ of 7 nM. UCB7362 inhibits *parasite* growth .

HY-144297

HDAC1-IN-3	HDAC Parasite	Infection
HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites .

HY-N12538

trans-Cinnamic anhydride	Parasite	Infection
trans-Cinnamic anhydride is a *Parasite* inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-14989

SQ109 3 Publications Verification NSC 722041	Parasite Bacterial Antibiotic	Infection
SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC₅₀ for cell killing of 50±8 nM. SQ109, targets MmpL3, is an antitubercular agent.

HY-120060

GNF6702	Parasite	Infection
GNF6702 is a selective inhibitor of the kinetoplastid proteasome. GNF6702 clears parasites in murine models of leishmaniasis, Chagas disease, and human African trypanosomiasis .

HY-155689

Antimalarial agent 30

Parasite Infection

Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .
HY-155688

Antimalarial agent 29

Parasite Infection

Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

Antimalarial agent 30	Parasite	Infection
Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

Antimalarial agent 29	Parasite	Infection
Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-13832

Atovaquone 1 Publications Verification Atavaquone	Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-156028

FIKK9.1-IN-1	Parasite	Infection
FIKK9.1-IN-1 (Compound 1) is a FIKK9.1 inhibitor. FIKK9.1-IN-1 interacts with the ATP?binding residues in FIKK9.1. FIKK9.1-IN-1 is an antimalarial agent (IC₅₀: 2.68 μg/mL) and disrupts the parasite life cycle and leads to the death of parasites .

HY-123601

DHQZ 36	Parasite	Infection
DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibits *Leishmania amazonensis* infection in macrophages with an EC₅₀ of 13.63 μM. DHQZ 36 has potent anti-parasite activity .

HY-132170

DSM502	Dihydroorotate Dehydrogenase Parasite	Infection
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs .

HY-118621

JCP174	Elastase Parasite	Infection
JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii . JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase .

HY-160611

TgENR-IN-1	Bacterial	Infection
TgENR-IN-1 (Compound 5a) is an inhibitor for Toxoplasma gondii enoyl reductase (TgENR), which inhibits 25% TgENR at 1 μM. TgENR-IN-1 exhibits toxicity with an IC₅₀ of >10 μM in parasite tissue .

HY-151151

Trypanothione synthetase-IN-3	Parasite	Infection
Trypanothione synthetase-IN-3 is a noncompetitive mixed hyperbolic Trypanothione synthetase (TryS) inhibitor (K_i: 0.8 μM). Trypanothione synthetase-IN-3 can be used in the study of parasites, such as L. infantum .

HY-13832S2

Atovaquone-d5 Atavaquone-d₅	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4 cis-Atavaquone-d₄	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-120924

BRD9185	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection
BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC₅₀ of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model .

HY-136450

Triclabendazole sulfoxide TCBZ-SO	Parasite BCRP	Infection
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP .

HY-D0008

Brilliant green	Bacterial Fungal Parasite	Infection
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal *parasites* and fungus. Brilliant green is effective against Gram-positive bacteria .

HY-113752

MMV019313	Parasite	Infection
MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC₅₀ of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .

HY-100184

DSM265 1 Publications Verification	Dihydroorotate Dehydrogenase Parasite	Infection
DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC₅₀ of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC₅₀ of 4.3 nM .

HY-18062

Pyrimethamine 5 Publications Verification Pirimecidan; Pirimetamin; RP 4753	Antifolate Parasite	Infection
Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is a cytochrome bc1 complex inhibitor with potent in vitro activity against a variety of Leishmania species. DNDI-6174 can reduce parasite burden in animal models of infection .

HY-132171

DSM705	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound .

HY-161299

LAPTc-IN-1	Parasite	Infection
LAPTc-IN-1 (compound 4) is a competitive inhibitor targeting acidic M17 leucinopeptidase (LAPTc) with K_i=0.27 μM. LAPTc-IN-1 is a potential antagonist of the parasite Trypanosoma cruzi .

HY-12912

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .

HY-119819

Psicofuranine	Bacterial Parasite Antibiotic	Infection
Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts *parasite* growth. Psicofuranine exhibits a dose-dependent inhibition of *P. falciparum* growth .

HY-128337

AN7973	Parasite	Infection
AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular *parasite* development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting agent candidate for treating cryptosporidiosis.

HY-B0621

Triclabendazole 4 Publications Verification CGA89317	Parasite Caspase Bcl-2 Family PARP Pyroptosis	Infection
Triclabendazole is an orally active *parasite* inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica .

HY-136307S

Tizoxanide-d4 glucuronide	Parasite	Infection
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

HY-148035

Plm IV inhibitor-2	Parasite	Infection
Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC₅₀ values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium *parasites* .

HY-N10197

Pulixin	Parasite Endogenous Metabolite	Infection
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-132931

TCMDC-125457	Parasite	Infection
TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-129476

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-N12538

trans-Cinnamic anhydride	Structural Classification Natural Products Source classification Cinnamomum verum J. Presl Plants Lauraceae	Parasite
trans-Cinnamic anhydride is a *Parasite* inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-N10197

Pulixin	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Coumarins Phenols Polyphenols Phenylpropanoids Disease Research Fields	Parasite Endogenous Metabolite
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM .

HY-N8181

1,3-Linolein-2-Olein	Infection Structural Classification Natural Products Classification of Application Fields Source classification Campanulaceae Plants Codonopsis thalictrifoliaWall. Disease Research Fields	Parasite
1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC₅₀=0.079 ug/ml) and inhibits the growth of amastigotes (IC₅₀= 40.03 ug/ml) .

HY-N1074

Warangalone Scandenolone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-15310

Ivermectin 15+ Cited Publications MK-933	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-N0281

Daphnetin 2 Publications Verification 7,8-Dihydroxycoumarin	Classification of Application Fields Daphne Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

Cat. No.	Product Name	Chemical Structure

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-136307S

Tizoxanide-d4 glucuronide
Tizoxanide-d₄ glucuronide is the deuterium labeled Tizoxanide glucuronide. Tizoxanide glucuronide is the metabolite of Nitazoxanide (HY-B0217) and is cell-permeable to inhibit asexual and sexual stages development of parasite C. parvum[1].

HY-136450S

Triclabendazole sulfoxide-d3
Triclabendazole sulfoxide-d₃ is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-136450S1

Triclabendazole sulfoxide-13C,d3
Triclabendazole sulfoxide- ¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

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